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1

Integrin-based therapeutics: biological basis, clinical use and new drugs

Ley, Klaus, Rivera-Nieves, Jesus, Sandborn, William J., Shattil, Sanford

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 400 KB

english, 2016

2

Platelet integrins and immunoreceptors

Ana Kasirer-Friede, Mark L. Kahn, Sanford J. Shattil

Journal:

Immunological Reviews

Year:

2007

Language:

english

File:

PDF, 640 KB

english, 2007

3

The final steps of integrin activation: the end game

Kim, Chungho, Ginsberg, Mark H., Shattil, Sanford J.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2010

Language:

english

File:

PDF, 884 KB

english, 2010

4

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

Ye, Feng, Petrich, Brian G., Anekal, Praju, Lefort, Craig T., Kasirer-Friede, Ana, Shattil, Sanford J., Ruppert, Raphael, Moser, Markus, Fässler, Reinhard, Ginsberg, Mark H.

Journal:

Current Biology

Year:

2013

Language:

english

File:

PDF, 2.10 MB

english, 2013

5

Optogenetic interrogation of integrin αVβ3 function in endothelial cells

Liao, Zhongji, Kasirer-Friede, Ana, Shattil, Sanford J.

Journal:

Journal of Cell Science

Year:

2017

Language:

english

File:

PDF, 6.46 MB

english, 2017

6

Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3

Kahner, Bryan N., Kato, Hisashi, Banno, Asoka, Ginsberg, Mark H., Shattil, Sanford J., Ye, Feng, Parsons, Maddy

Journal:

Year:

2012

Language:

english

File:

PDF, 912 KB

english, 2012

7

The zebrafish vitronectin receptor: Characterization of integrin αV and β3 expression patterns in early vertebrate development

Ararat J. Ablooglu, Jian Kang, Robert I. Handin, David Traver, Sanford J. Shattil

Journal:

Developmental Dynamics

Year:

2007

Language:

english

File:

PDF, 442 KB

english, 2007

8

Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex

Hema Rangaswami, Raphaela Schwappacher, Nisha Marathe, Darren E Casteel, Bodo Haas, Alexander Pfeifer, Sanford Shattil, Gerry Boss, Renate B Pilz

Journal:

BMC Pharmacology

Year:

2011

Language:

english

File:

PDF, 147 KB

english, 2011

9

Editorial

Sanford Shattil, Finbarr Cotter

Journal:

British Journal of Haematology

Year:

2006

Language:

english

File:

PDF, 26 KB

english, 2006

10

10.1038/35060120

Kiosses, William B., Shattil, Sanford J., Pampori, Nisar, Schwartz, Martin Alexander

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 1.44 MB

english, 2001

11

10.1038/ni1001-904

Woodside, Darren G., Shattil, Sanford J., Ginsberg, Mark H.

Journal:

Nature Immunology

Year:

2001

Language:

english

File:

PDF, 49 KB

english, 2001

12

10.1038/ni1001-906

Woodside, Darren G., Shattil, Sanford J., Ginsberg, Mark H.

Journal:

Nature Immunology

Year:

2001

Language:

english

File:

PDF, 27 KB

english, 2001

13

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

Prévost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A, Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K

Journal:

Nature Medicine

Year:

2009

Language:

english

File:

PDF, 1.16 MB

english, 2009

14

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor

Wiedmer, Therese, Shattil, Sanford J., Cunningham, Michael, Sims, Peter J.

Journal:

Year:

1990

Language:

english

File:

PDF, 2.88 MB

english, 1990

15

Regulation of protein tyrosine kinases in platelets

Edwin A. Clark, Sanford J. Shattil, Joan S. Brugge

Journal:

Trends in Biochemical Sciences

Year:

1994

Language:

english

File:

PDF, 660 KB

english, 1994

16

Integrin regulation

Mark H Ginsberg, Anthony Partridge, Sanford J Shattil

Journal:

Current Opinion in Cell Biology

Year:

2005

Language:

english

File:

PDF, 313 KB

english, 2005

17

Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

Jaewon Han, Chinten James Lim, Naohide Watanabe, Alessandra Soriani, Boris Ratnikov, David A. Calderwood, Wilma Puzon-McLaughlin, Esther M. Lafuente, Vassiliki A. Boussiotis, Sanford J. Shattil, Mark

Journal:

Current Biology

Year:

2006

Language:

english

File:

PDF, 715 KB

english, 2006

18

Integrins and Src: dynamic duo of adhesion signaling

Sanford J. Shattil

Journal:

Trends in Cell Biology

Year:

2005

Language:

english

File:

PDF, 311 KB

english, 2005

19

Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains

Darren G. Woodside, Achim Obergfell, Lijun Leng, Julie L. Wilsbacher, Cindy K. Miranti, Joan S. Brugge, Sanford J. Shattil, Mark H. Ginsberg

Journal:

Current Biology

Year:

2001

Language:

english

File:

PDF, 361 KB

english, 2001

20

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

Cindy K. Miranti, Lijun Leng, Petra Maschberger, Joan S. Brugge, Sanford J. Shattil

Journal:

Current Biology

Year:

1998

Language:

english

File:

PDF, 2.22 MB

english, 1998

21

Signaling networks linking integrins and Rho family GTPases

Martin A Schwartz, Sanford J Shattil

Journal:

Trends in Biochemical Sciences

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

22

A Mechanism for Modulation of Cellular Responses to VEGF: Activation of the Integrins

Tatiana V. Byzova, Corey K. Goldman, Nisar Pampori, Kenneth A. Thomas, Andrew Bett, Sanford J. Shattil, Edward F. Plow

Journal:

Year:

2000

Language:

english

File:

PDF, 633 KB

english, 2000

23

An enzyme-linked immunosorbent assay to identify inhibitors of activation of platelet integrin αIIbβ3

Jingbo Gao, Sanford J. Shattil

Journal:

Journal of Immunological Methods

Year:

1995

Language:

english

File:

PDF, 939 KB

english, 1995

24

Characterization of α2-adrenergic receptors on human platelets using [3H]yohimbine

Harvey J. Motulsky, Sanford J. Shattil, Paul A. Insel

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 393 KB

english, 1980

25

Use of monoclonal antibodies to study the interaction between an integrin adhesion receptor, GP IIb-IIIa, and its physiological ligand, fibrinogen

Sanford J. Shattil, John W. Weisel, Thomas Kieber-Emmons

Journal:

Year:

1992

Language:

english

File:

PDF, 1.27 MB

english, 1992

26

Protein tyrosine phosphorylation and the adhesive functions of platelets

Shattil, Sanford J., Brugge, Joan S.

Journal:

Current Opinion in Cell Biology

Year:

1991

Language:

english

File:

PDF, 2.12 MB

english, 1991

27

Inhibitors of platelet binding

Shattil, Sanford J, Taub, Rebecca A, Friedman, Paul

Journal:

Transfusion Science

Year:

1993

Language:

english

File:

PDF, 81 KB

english, 1993

28

A Genetic Analysis of Integrin Function: Glanzmann Thrombasthenia in vitro

Elizabeth K. Baker, Eileen Collins Tozer, Martin Pfaff, Sanford J. Shattil, Joseph C. Loftus and Mark H. Ginsberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.23 MB

english, 1997

29

Primary Megakaryocytes Reveal a Role for Transcription Factor NF-E2 in Integrin αIIbβ3 Signaling

Masamichi Shiraga, Alec Ritchie, Sallouha Aidoudi, Veronique Baron, David Wilcox, Gilbert White, Belen Ybarrondo, George Murphy, Andrew Leavitt and Sanford Shattil

Journal:

The Journal of Cell Biology

Year:

1999

Language:

english

File:

PDF, 3.43 MB

english, 1999

30

Affinity Modulation of Platelet Integrin αIIbβ3by β3-Endonexin, a Selective Binding Partner of the β3Integrin Cytoplasmic Tail

Hirokazu Kashiwagi, Martin A. Schwartz, Martin Eigenthaler, K. A. Davis, Mark H. Ginsberg and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

1997

Language:

english

File:

PDF, 2.93 MB

english, 1997

31

Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3

Takaaki Hato, Nisar Pampori and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

1998

Language:

english

File:

PDF, 3.42 MB

english, 1998

32

β3-Endonexin, a Novel Polypeptide That Interacts Specifically with the Cytoplasmic Tail of the Integrin β3Subunit

Sanford J. Shattil, Timothy O'Toole, Martin Eigenthaler, Vicki Thon, Michael Williams, Bernard M. Babior and Mark H. Ginsberg

Journal:

The Journal of Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

33

Integrin Cytoplasmic Domains Mediate Inside-out Signal Transduction

Timothy E. O'Toole, Yasuhiro Katagiri, Randall J. Faull, Karlheinz Peter, Richard Tamura, Vito Quaranta, Joseph C. Loftus, Sanford J. Shattil and Mark H. Ginsberg

Journal:

The Journal of Cell Biology

Year:

1994

Language:

english

File:

PDF, 3.03 MB

english, 1994

34

Adhesive Ligand Binding to Integrin αIIbβ3Stimulates Tyrosine Phosphorylation of Novel Protein Substrates before Phosphorylation of pp125FAK

Min-Mei Huang, Lorraine Lipfert, Michael Cunningham, Joan S. Brugge, Mark H. Ginsberg and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

1993

Language:

english

File:

PDF, 3.10 MB

english, 1993

35

Part 2 || Role of Platelet Membrane Glycoprotein IIb-IIIa in Agonist-Induced Tyrosine Phosphorylation of Platelet Proteins

Andy Golden, Joan S. Brugge and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

1990

Language:

english

File:

PDF, 3.24 MB

english, 1990

36

Syk, c-Src, the αvβ3 Integrin, and ITAM Immunoreceptors, in Concert, Regulate Osteoclastic Bone Resorption

Wei Zou, Hideki Kitaura, Jennifer Reeve, Fanxin Long, Victor L. J. Tybulewicz, Sanford J. Shattil, Mark H. Ginsberg, F. Patrick Ross and Steven L. Teitelbaum

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 3.13 MB

english, 2007

37

Proximal, Selective, and Dynamic Interactions between Integrin αIIbβ3 and Protein Tyrosine Kinases in Living Cells

Maddalena de Virgilio, William B. Kiosses and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

2004

Language:

english

File:

PDF, 2.13 MB

english, 2004

38

Coordinate Interactions of Csk, Src, and Syk Kinases with αIIbβ3 Initiate Integrin Signaling to the Cytoskeleton

Achim Obergfell, Koji Eto, Attila Mocsai, Charito Buensuceso, Sheri L. Moores, Joan S. Brugge, Clifford A. Lowell and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

2002

Language:

english

File:

PDF, 1.70 MB

english, 2002

39

Integrin αvβ3 Drives Slug Activation and Stemness in the Pregnant and Neoplastic Mammary Gland

Desgrosellier, Jay S., Lesperance, Jacqueline, Seguin, Laetitia, Gozo, Maricel, Kato, Shumei, Franovic, Aleksandra, Yebra, Mayra, Shattil, Sanford J., Cheresh, David A.

Journal:

Developmental Cell

Year:

2014

Language:

english

File:

PDF, 4.11 MB

english, 2014

40

The Clinical Importance of Acquired Abnormalities of Platelet Function

George, James N., Shattil, Sanford J.

Journal:

Boston Medical and Surgical Journal

Year:

1991

Language:

english

File:

PDF, 2.45 MB

english, 1991

41

Relationships between membrane cholesterol, α-adrenergic receptors, and platelet function

Insel, Paul A., Nirenberg, Peter, Turnbull, Judy, Shattil, Sanford J.

Journal:

Year:

1978

Language:

english

File:

PDF, 703 KB

english, 1978

42

Membrane microviscosity and human platelet function

Shattil, Sanford J., Cooper, Richard A.

Journal:

Year:

1976

Language:

english

File:

PDF, 710 KB

english, 1976

43

Factors influencing the lipid composition and fluidity of red cell membranes in vitro: production of red cells possessing more than two cholesterols per phospholipid

Cooper, Richard A., Leslie, Mary H., Fischkoff, Steven, Shinitzky, Meir, Shattil, Sanford J.

Journal:

Year:

1978

Language:

english

File:

PDF, 608 KB

english, 1978

44

Microfluidic devices for studies of shear-dependent platelet adhesion

Gutierrez, Edgar, Petrich, Brian G., Shattil, Sanford J., Ginsberg, Mark H., Groisman, Alex, Kasirer-Friede, Ana

Journal:

Year:

2008

Language:

english

File:

PDF, 515 KB

english, 2008

45

Lateral Clustering of Platelet GP Ib-IX Complexes Leads to Up-regulation of the Adhesive Function of Integrin α IIb β 3

Kasirer-Friede, Ana, Ware, Jerry, Leng, Lijun, Marchese, Patrizia, Ruggeri, Zaverio M., Shattil, Sanford J.

Journal:

Journal of Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 648 KB

english, 2002

46

Specification of the Direction of Adhesive Signaling by the Integrin β Cytoplasmic Domain

Arias-Salgado, Elena G., Lizano, Sergio, Shattil, Sanford J., Ginsberg, Mark H.

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 1.04 MB

english, 2005

47

Protein-Protein Interactions in Platelet α IIb β 3 Signaling

Buensuceso, Charito S, Arias-Salgado, Elena G, Shattil, Sanford J

Journal:

Seminars in Thrombosis and Hemostasis

Year:

2004

Language:

english

File:

PDF, 191 KB

english, 2004

48

Mechanisms and Consequences of Agonist-Induced Talin Recruitment to Platelet Integrin αiibβ3

Naohide Watanabe, Laurent Bodin, Manjula Pandey, Matthias Krause, Shaun Coughlin, Vassiliki A. Boussiotis, Mark H. Ginsberg and Sanford J. Shattil

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 3.52 MB

english, 2008

49

Membrane Cholesterol — Is Enough Too Much?

Cooper, Richard A., Shattil, Sanford J.

Journal:

Boston Medical and Surgical Journal

Year:

1980

File:

PDF, 520 KB

1980

50

Platelet Function in Essential Thrombocythemia

Kaywin, Paul, McDonough, Margaret, Insel, Paul A., Shattil, Sanford J.

Journal:

Boston Medical and Surgical Journal

Year:

1978

Language:

english

File:

PDF, 1.42 MB

english, 1978

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